SHLD2 localizations
SHLD2 [ENSP00000298786]
Shieldin complex subunit 2; Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres ; Belongs to the SHLD2 family.
Synonyms: SHLD2, SHLD2p, hSHLD2, Q86V20, U3KQ89 ...