COMPARTMENTS

NOD2 [ENSP00000300589]

Nucleotide-binding oligomerization domain-containing protein 2; Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages . Component of an autophagy-mediated antibacterial pathway together with ATG16L1 . Plays also a role in sensing single-stranded RNA (ssRNA) from viruses. Interacts with mitochondrial antiviral signaling/MAVS, leading to activation of interferon regulatory factor-3/IRF3 and expression of type I interferon . ECO:0000269|PubMed:19701189, ECO:0000269|PubMed:20637199,

Synonyms:  NOD2,  NOD2p,  hNOD2,  A0A286YF65,  E9PK30 ...

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