COMPARTMENTS

GSDMA [ENSP00000301659]

Gasdermin-A; May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)- bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity . The physiological relevance of these observations is unknown (Probable).

Synonyms:  GSDMA,  J3KRG2,  Q96QA5,  J3KRG2p,  hJ3KRG2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM