COMPARTMENTS

CBR4 [ENSP00000303525]

Carbonyl reductase family member 4; The heterotetramer with HSD17B8 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis (PubMed:19571038, PubMed:25203508). Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD . The homotetramer has NADPH-dependent quinone reductase activity . Both homotetramer and the heterotetramer have broad substrate specificity and can reduce 9,10- phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro) (PubMed:19000905, PubMed:19571038, PubMed:25203508).

Synonyms:  CBR4,  CBR4p,  hCBR4,  D6RAV8,  D6RGF2 ...

Linkouts:  STRING  Pharos  UniProt