COMPARTMENTS

NKIRAS2 [ENSP00000303580]

NF-kappa-B inhibitor-interacting Ras-like protein 2; Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity); Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

Synonyms:  NKIRAS2,  NKIRAS2p,  hNKIRAS2,  A0A024R1Z4,  A0A0A0MTA0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM