TWNK localizations
TWNK [ENSP00000309595]
Twinkle protein, mitochondrial; Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime maintenance of mtDNA integrity. In vitro, forms in combination with POLG, a processive replication machinery, which can use double-stranded DNA (dsDNA) as template to synthesize single-stranded DNA (ssDNA) molecules. May be a key regulator of mtDNA copy number in mammals.
Synonyms: TWNK, A0A2R8Y4V4, A0A2R8Y746, A0A2R8Y8D3, A0A2R8YF85 ...
Linkouts: STRING Pharos UniProt
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