COMPARTMENTS

CFLAR [ENSP00000312455]

CASP8 and FADD-like apoptosis regulator subunit p12; Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. ; Belongs to the peptidase C14A family.

Synonyms:  CFLAR,  A0A024R3Y3,  A0A024R3Z7,  A0A0A0MR92,  A0A336TY74 ...

Linkouts:  STRING  Pharos  UniProt  OMIM