COMPARTMENTS

CHRNA9 [ENSP00000312663]

Neuronal acetylcholine receptor subunit alpha-9; Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane . The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane . In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion .

Synonyms:  CHRNA9,  CHRNA9p,  hCHRNA9,  Q9UGM1,  Q9UGM1p ...

Linkouts:  STRING  Pharos  UniProt  OMIM