COMPARTMENTS

IMPDH2 [ENSP00000321584]

Inosine-5'-monophosphate dehydrogenase 2; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.

Synonyms:  IMPDH2,  IMPDH2p,  hIMPDH2,  A0A384N6C2,  E7ETK5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM