COMPARTMENTS

FAM20C [ENSP00000322323]

Extracellular serine/threonine protein kinase FAM20C; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth (PubMed:22582013, PubMed:23754375, PubMed:25789606). Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome . Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity . Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1 . In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion . ; Belongs to the FAM20 family.

Synonyms:  FAM20C,  FAM20Cp,  hFAM20C,  Q8IXL6,  Q8IXL6p ...

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