COMPARTMENTS

MED16 [ENSP00000325612]

Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Synonyms:  MED16,  MED16p,  hMED16,  A0A087WU12,  B9TWZ6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM