COMPARTMENTS

SPSB1 [ENSP00000330221]

SPRY domain-containing SOCS box protein 1; Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins . Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 . Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 .

Synonyms:  SPSB1,  SPSB1p,  hSPSB1,  A0A024R4G8,  A2A276 ...

Linkouts:  STRING  Pharos  UniProt  OMIM