PTCH1 localizations
PTCH1 [ENSP00000332353]
Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. ; Belongs to the patched family.
Synonyms: PTCH1, PTCH1p, hPTCH1, A0A0C4DGI4, A0A0C4DGJ5 ...
Linkouts: STRING Pharos UniProt OMIM
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