COMPARTMENTS

SKA2 [ENSP00000333433]

Spindle and kinetochore-associated protein 2; Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint . The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies . The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization- coupled manner . In the complex, it is required for SKA1 localization . Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules .

Synonyms:  SKA2,  SKA2p,  hSKA2,  J3KRW9,  J3KRZ0 ...

Linkouts:  STRING  Pharos  UniProt