COMPARTMENTS

BTLA [ENSP00000333919]

B- and T-lymphocyte attenuator; Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 . May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 . In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells . ECO:0000269|PubMed:14652006, ECO:0000269|PubMed:15568026,

Synonyms:  BTLA,  Q7Z6A9,  Q7Z6A9p,  hQ7Z6A9,  151888 ...

Linkouts:  STRING  Pharos  UniProt  OMIM