COMPARTMENTS

SPDYA [ENSP00000335628]

Speedy protein A; Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2 . Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate- binding cleft prior to kinase activation . Mediates cell survival during the DNA damage process through activation of CDK2 . ECO:0000269|PubMed:12839962, ECO:0000269|PubMed:12972555,; Belongs to the Speedy/Ringo family.

Synonyms:  SPDYA,  A0A384MTT5,  E7EPV1,  H7C0J1,  Q5MJ70 ...

Linkouts:  STRING  Pharos  UniProt  OMIM