COMPARTMENTS

SRA1 [ENSP00000337513]

Steroid receptor RNA activator 1; Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N- terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis. ECO:0000269|PubMed:12943696, ECO:0000269|PubMed:14517287,; Belongs to the SRA1 family.

Synonyms:  SRA1,  SRA1p,  hSRA1,  Q9HD15,  R4GMW4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM