COMPARTMENTS

DMP1 [ENSP00000340935]

Dentin matrix acidic phosphoprotein 1; May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast- specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite.

Synonyms:  DMP1,  DMP1p,  hDMP1,  Q13316,  Q13316p ...

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