COMPARTMENTS

LAMTOR4 [ENSP00000343118]

Ragulator complex protein LAMTOR4, N-terminally processed; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated; Belongs to the LAMTOR4 family.

Synonyms:  LAMTOR4,  LAMTOR4p,  hLAMTOR4,  A0A087WT92,  A0A087WV46 ...

Linkouts:  STRING  Pharos  UniProt