COMPARTMENTS

GPR18 [ENSP00000343428]

N-arachidonyl glycine receptor; Receptor for endocannabinoid N-arachidonyl glycine (NAGly) . However, conflicting results about the role of NAGly as an agonist are reported . Can also be activated by plant-derived and synthetic cannabinoid agonists . The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase . May contribute to regulation of the immune system. Is required for normal homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs)in small intstine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (By similarity). Plays a role in hypotensive responses, mediating reduction in intraocular and blood pressure (By similarity). Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis .

Synonyms:  GPR18,  GPR18p,  hGPR18,  H9NIM1,  Q14330 ...

Linkouts:  STRING  Pharos  UniProt  OMIM