COMPARTMENTS

ZFYVE19 [ENSP00000347498]

Abscission/NoCut checkpoint regulator; Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.

Synonyms:  ZFYVE19,  ZFYVE19p,  hZFYVE19,  H3BN64,  H3BP54 ...

Linkouts:  STRING  Pharos  UniProt