COMPARTMENTS

ICK [ENSP00000349458]

Serine/threonine-protein kinase ICK; Required for ciliogenesis . Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length . Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a key role in the development of multiple organ systems and particularly in cardiac development (By similarity). Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling- dependent manner and this regulation requires its kinase activity (By similarity). ECO:0000250|UniProtKB:Q9JKV2, ECO:0000269|PubMed:24797473,; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Synonyms:  ICK,  A0A024RD59,  Q9UPZ9,  Q9UPZ9p,  hQ9UPZ9 ...

Linkouts:  STRING  Pharos  UniProt