COMPARTMENTS

ELK4 [ENSP00000350681]

ETS domain-containing protein Elk-4; Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously.

Synonyms:  ELK4,  ELK4p,  hELK4,  A0A024R997,  A0A024R9C2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM