COMPARTMENTS

NOTCH2NLA [ENSP00000354929]

Notch homolog 2 N-terminal-like protein A; Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed:29856954, PubMed:29856955, PubMed:29561261). Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production . Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect . Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 . Also promotes Notch signaling pathway in a cell- autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation (By similarity).

Synonyms:  NOTCH2NLA,  NOTCH2NLC,  P0DPK4,  Q7Z3S9,  P0DPK4p ...

Linkouts:  STRING  Pharos  UniProt