COMPARTMENTS

RYR2 [ENSP00000355533]

Ryanodine receptor 2; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. ; Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR2 subfamily.

Synonyms:  RYR2,  RYR2p,  hRYR2,  H7BY35,  Q92736 ...

Linkouts:  STRING  Pharos  UniProt  OMIM