COMPARTMENTS

CD55 [ENSP00000356030]

Complement decay-accelerating factor; This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade . Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage . (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable).

Synonyms:  CD55,  CD55p,  hCD55,  A0A2R8Y4B4,  A0A2R8YDY3 ...

Linkouts:  STRING  Pharos  UniProt