COMPARTMENTS

PYHIN1 [ENSP00000357122]

Pyrin and HIN domain-containing protein 1; Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells.

Synonyms:  PYHIN1,  PYHIN1p,  hPYHIN1,  Q6K0P9,  X6RHR0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM