COMPARTMENTS

BAG3 [ENSP00000358081]

BAG family molecular chaperone regulator 3; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 . Has anti- apoptotic activity . Plays a role in the HSF1 nucleocytoplasmic transport . ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:27474739,

Synonyms:  BAG3,  BAG3p,  hBAG3,  C9JFK9,  O95817 ...

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