COMPARTMENTS

CD40LG [ENSP00000359663]

CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 . Costimulates T-cell proliferation and cytokine production . Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation . Induces the activation of NF-kappa-B . Induces the activation of kinases MAPK8 and PAK2 in T-cells . Induces tyrosine phosphorylation of isoform 3 of CD28 . Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity). ECO:0000269|PubMed:1280226, ECO:0000269|PubMed:15067037,; Belongs to the tumor necrosis factor family.

Synonyms:  CD40LG,  CD40LGp,  hCD40LG,  P29965,  Q3L8U2 ...

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