COMPARTMENTS

ARRDC1 [ENSP00000360475]

Arrestin domain-containing protein 1; Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates . Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles . More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles . By participating to the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway ; Belongs to the arrestin family.

Synonyms:  ARRDC1,  ARRDC1p,  hARRDC1,  F2Z3I4,  Q5T370 ...

Linkouts:  STRING  Pharos  UniProt