COMPARTMENTS

ADA [ENSP00000361965]

Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine . Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4 . Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion . Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity). Enhances CD4+ T-cell differentiation and proliferation . Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change . Stimulates plasminogen activation . Plays a role in male fertility . Plays a protective role in early postimplantation embryonic development (By similarity). ECO:0000269|PubMed:11772392, ECO:0000269|PubMed:15016824, ECO:0000269|PubMed:16670267, ECO:0000269|PubMed:20959412, ECO:0000269|PubMed:21919946, ECO:0000269|PubMed:23193172,

Synonyms:  A0A0S2Z381,  F5GWI4,  F5GXW0,  F5GYD4,  P00813 ...

Linkouts:  STRING  Pharos  UniProt  OMIM