COMPARTMENTS

DKK1 [ENSP00000363081]

Dickkopf-related protein 1; Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 . DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease . Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity). ; Belongs to the dickkopf family.

Synonyms:  DKK1,  DKK1p,  hDKK1,  I1W660,  O94907 ...

Linkouts:  STRING  Pharos  UniProt  OMIM