COMPARTMENTS

UBR4 [ENSP00000364403]

E3 ubiquitin-protein ligase UBR4; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin- mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation; Belongs to the UBR4 family.

Synonyms:  UBR4,  UBR4p,  hUBR4,  A0A0A0MSW0,  Q5T4S7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM