COMPARTMENTS

CYBB [ENSP00000367851]

Cytochrome b-245 heavy chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.

Synonyms:  CYBB,  A0A0S2Z3S6,  P04839,  P04839p,  hP04839 ...

Linkouts:  STRING  Pharos  UniProt  OMIM