COMPARTMENTS

IL33 [ENSP00000370842]

Interleukin-33 (109-270); Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells . Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury . ; Belongs to the IL-1 family. Highly divergent.

Synonyms:  IL33,  IL33p,  hIL33,  O95760,  O95760p ...

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