ACVRL1 localizations
ACVRL1 [ENSP00000373574]
Serine/threonine-protein kinase receptor R3; Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.
Synonyms: ACVRL1, ACVRL1p, hACVRL1, A0A0S2Z310, D9IPD9 ...
Linkouts: STRING Pharos UniProt OMIM
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