COMPARTMENTS

STEAP3 [ENSP00000376822]

Metalloreductase STEAP3; Endosomal ferrireductase required for efficient transferrin- dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.

Synonyms:  STEAP3,  STEAP3p,  hSTEAP3,  A0A024RAD7,  B8ZZX6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM