COMPARTMENTS

ILK [ENSP00000379975]

Integrin-linked protein kinase; Receptor-proximal protein kinase regulating integrin-mediated signal transduction . May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B (PubMed:8538749, PubMed:9736715).

Synonyms:  ILK,  A0A087WW45,  A0A087WWY6,  A0A0A0MTH3,  E9PQ52 ...

Linkouts:  STRING  Pharos  UniProt