CARD11 localizations
CARD11 [ENSP00000380150]
Caspase recruitment domain-containing protein 11; Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway. ECO:0000269|PubMed:11356195, ECO:0000269|PubMed:12356734,
Synonyms: CARD11, CARD11p, hCARD11, A0A024R854, E2QRC0 ...
Linkouts: STRING Pharos UniProt OMIM
Fetching ...
Fetching ...
Fetching ...