COMPARTMENTS

TM9SF4 [ENSP00000381104]

Transmembrane 9 superfamily member 4; Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface . Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells . Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the pH regulation of the intracellular vesicles in tumor cells .

Synonyms:  TM9SF4,  TM9SF4p,  hTM9SF4,  A0A024QYR3,  A0A0C4DFM1 ...

Linkouts:  STRING  Pharos  UniProt