OPRPN localizations
OPRPN [ENSP00000382485]
Opiorphin prepropeptide; Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC(50) values of 29 uM, 33 uM and 33 uM respectively. Inhibits the breakdown of Ala-pNA by aminopeptidase N in vitro with an IC(50) of 65 uM. Has a potent analgesic effect when administered to rats by intravenous injection. ; Belongs to the PROL1/PROL3 family.
Synonyms: OPRPN, Q99935, Q99935p, hQ99935, 58503 ...
Linkouts: STRING Pharos UniProt OMIM
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