COMPARTMENTS

CECR2 [ENSP00000383428]

Cat eye syndrome critical region protein 2; Chromatin reader component of histone-modifying complexes, such as the CERF (CECR2-containing-remodeling factor) complex and ISWI- type complex . It thereby plays a role in various processes during development: required during embryogenesis for neural tube closure and inner ear development. In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes (By similarity). In histone-modifying complexes, CECR2 recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated . May also be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis . ECO:0000269|PubMed:11827465, ECO:0000269|PubMed:15640247,

Synonyms:  CECR2,  CECR2p,  hCECR2,  A0A087WT21,  A0A0R4J2E1 ...

Linkouts:  STRING  Pharos  UniProt