COMPARTMENTS

NLRX1 [ENSP00000387334]

NLR family member X1; Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction . Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 . Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis . Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species .

Synonyms:  NLRX1,  NLRX1p,  hNLRX1,  C9J0R6,  C9JLK8 ...

Linkouts:  STRING  Pharos  UniProt