COMPARTMENTS

GPSM1 [ENSP00000392828]

G-protein-signaling modulator 1; Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein- coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. ; Belongs to the GPSM family.

Synonyms:  GPSM1,  GPSM1p,  hGPSM1,  A0A087WVF5,  A0A0A0MRC4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM