ZNF304 localizations
ZNF304 [ENSP00000401642]
Zinc finger protein 304; Acts as transcriptional regulator and plays a role in gene silencing . Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of several tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells . Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) by inducing trimethylation of 'Lys-27' of histone H3 (H3K27me3) in a Polycomb group (PcG) complexes-dependent manner. Associates at promoter regions of TSGs and mediates the recruitment of the corepressor complex containing the scaffolding protein TRIM28, methyltransferase DNMT1 and histone methyltransferase SETDB1 and/or the PcG complexes at those sites . Transcription factor involved in the metastatic cascade process by inducing cell migration and proliferation and gain resistance to anoikis of ovarian carcinoma (OC) cells via integrin- mediated signaling pathways . Associates with the ITGB1 promoter and positively regulates beta-1 integrin transcription expression . Promotes angiogenesis . Promotes tumor growth . ; Belongs to the krueppel C2H2-type zinc-finger protein family.
Synonyms: ZNF304, E7EQD3, M0QZ59, Q9HCX3, ZNF304p ...