COMPARTMENTS

BRAP [ENSP00000403524]

BRCA1-associated protein; Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.

Synonyms:  BRAP,  J3KNN7,  Q7Z569,  J3KNN7p,  hJ3KNN7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM