COMPARTMENTS

ILF3 [ENSP00000404121]

Interleukin enhancer-binding factor 3; RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back- splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs . As a consequence, participates in a wide range of transcriptional and post- transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs . Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response . Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA- activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs .

Synonyms:  ILF3,  ILF3p,  hILF3,  A0A024R7C7,  K7EJ09 ...

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