COMPARTMENTS

PPP2CA [ENSP00000418447]

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'. ECO:0000269|PubMed:10801873, ECO:0000269|PubMed:22613722,

Synonyms:  PPP2CA,  PPP2CAp,  hPPP2CA,  B3KUN1,  E5RHP4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM