SHLD3 localizations
SHLD3 [ENSP00000424007]
Shieldin complex subunit 3; Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres.
Synonyms: SHLD3, SHLD3p, hSHLD3, Q6ZNX1, Q6ZNX1p ...