COMPARTMENTS

LAMTOR3 [ENSP00000424183]

Ragulator complex protein LAMTOR3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.

Synonyms:  LAMTOR3,  LAMTOR3p,  hLAMTOR3,  Q9UHA4,  Q9UHA4p ...

Linkouts:  STRING  Pharos  UniProt